ORO ROSELLE GEL

Buah roselle yang segar digunakan untuk menyediakan jus dan kaliks buah roselle kering pula digunakan untuk menyediakan teh masam (sour tea). Petua tradisional masyarakat nusantara, cina, india dan asia barat juga mencadangkan penggunaan teh masam untuk kesihatan.

Nama saintifik pokok roselle ialah Hibiscus sabdariffa yang berada dalam famili Malvaceae. 

Kajian saintifik berikut mengusulkan bahawa bahan kimia alami yang dikenali anthocyanin dan vitamin C yang terkandung dalam kaliks buah roselle berupaya memberi kesan antioksida yang kuat iaitu menghalang kerosakan sel kulit dan penuaan permukaan kulit akibat pendedahan kepada cahaya matahari yang berpanjangan.

• Firas Al-Niaimi, and Nicole Yi Zhen Chiang. Topical Vitamin C and The Skin: Mechanisms of action and clinical applications. Journal of Clinical Aesthetic Dermatology. 2017:10(7):14–17.  

• Ines Da-Costa-Rocha, Bernd Bonnlaender, Hartwig Sievers, Ivo Pischel, Micheal Heinrich. Hibiscus sabdariffa L. A Phytochemical and Pharmacological review. Food Chemistry 165 (2014) 424-443.

• Octavio Carvajal-Zarrabal, Dulce María Barradas-Dermitz, Zaida Orta-Flores, Patricia Margaret Hayward-Jones, Cirilo Nolasco-Hipólito, M Guadalupe AguilarUscanga, Anilú Miranda-Medina and Kopli Bujang. Hibiscus sabdariffa L., Roselle Calyx, from Ethnobotany to Pharmacology. Journal of Experimental Pharmacology. 2012:4: 25-39.

• Pi-Jen Tsai, John McIntosh, Philip Pearce, Blake Camden, Brian R Jordan. Anthocyanin and antioxidant capacity in Roselle (Hibiscus sabdariffa L.) extract. Food Research International Volume 35, Issue 4, 2002, Pages 351-356.

• Ru Da Pandel, Borut Poljšak, Aleksandar Godic and Raja Dahmane. Skin Photoaging and the Role of Antioxidants in Its Prevention. ISRN Dermatology, Volume 2013,11 pages.

Maklumat pada halaman ini bertujuan pendidikan kesihatan awam dan bukan untuk indikasi ubatan sesuatu produk.

Information at this page is intended for public health education and not for product claim or indication of a product.

ORO-CLOVE-GEL

Bunga cengkih merupakan rempah ratus yang lazim digunakan dalam masakan. Petua tradisional juga mencadangkan penggunaan cengkih untuk kesihatan.

Nama saintifik pokok cengkih ialah Syzigium aromaticum atau Eugenia caryophyllata yang berada dalam famili Myrtaceae. 

Kajian saintifik berikut mengusulkan bahawa bahan kimia alami yang dikenali Eugenol terkandung dalam bunga cengkih yang berupaya memberi kesan anestetik iaitu bersifat seperti ubat bius untuk tidak berasa sakit. Ekstrak cengkih juga memiliki kesan antimikrobial iaitu berupaya membunuh bakteria. Secara menyeluruh memiliki ciri-ciri yang bagus untuk melindungi kesihatan gigi dan gusi.

• Alqareer A , Alyahya A, Andersson L. The effect of clove and benzocaine versus placebo as topical anesthetics. Journal of Dentistry. 2006: 34(10): 747-50.

• Chaieb K , Hajlaoui H, Zmantar T, Kahla-Nakbi AB, Rouabhia M, Mahdouani K, Bakhrouf A. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. Phytotherapy Research. 2007:21(6):501-6.

• Charu M. Marya, Gunjan Satija, Avinash J., Ruchi Nagpal, Rohtash Kapoor, and Aijaz Ahmad. In Vitro Inhibitory Effect of Clove Essential Oil and Its Two Active Principles on Tooth Decalcification by Apple Juice. International Journal of Dentistry, Volume 2012, Article ID 759618, 6 pages.

• Diego Francisco Cortés-Rojas, Claudia Regina Fernandes de Souza, Wanderley Pereira Oliveira. Clove (Syzygium aromaticum): a precious spice. Asian Pacific Journal of Tropical Biomedical 2014: 4(2): 90-96.

• Haizhou Liu, John C. Schmitz Jianteng Wei, Shousong Cao, Jan H. Beumer, Sandra Strychor, Linyou Cheng, Ming Liu, Cuicui Wang, Ning Wu, Xiangzhong Zhao, Yuyan Zhang, Joshua Liao, Edward Chu and Xiukun Lin. Clove Extract Inhibits Tumor Growth and Promotes Cell Cycle Arrest and Apoptosis. Oncology Research. 2014:21(5):247–259.

• Percival SS , Vanden Heuvel JP, Nieves CJ, Montero C, Migliaccio AJ, Meadors J. Bioavailability of herbs and spices in humans as determined by ex-vivo inflammatory suppression and DNA strand breaks. Journal of American College of Nutrition. 2012:31(4):288-94.

Maklumat pada halaman ini bertujuan pendidikan kesihatan awam dan bukan untuk indikasi ubatan sesuatu produk.

Information at this page is intended for public health education and not for product claim or indication of a product.

ORO PIPER GEL

Biji lada hitam merupakan rempah ratus yang lazim digunakan dalam masakan. Petua tradisional juga mencadangkan penggunaan lada hitam untuk kesihatan.

Nama saintifik pokok lada hitam ialah Piper nigrum yang berada dalam famili Piperaceae diklasifikasikan oleh ahli taksonomi Linnaeus pada tahun 1753.

Kajian saintifik berikut mengusulkaN kimia alami yang dikenali Piperine terkandung dalam biji lada hitam yang berupaya memberi kesan analgesik iaitu mengurangi rasa sakit.

• Bukhari IA , Pivac N, Alhumayyd MS, Mahesar AL, Gilani AH. The analgesic and anticonvulsant effects of piperine in mice. Journal of Physiological Pharmacology. 2013:64(6):789-94.

• Evan Prince Sabinaa, Aayesha Nasreen b, Mahima Vedi a, Mahaboobkhan Rasool. Analgesic, Antipyretic and Ulcerogenic Effects of Piperine: An Active Ingredient of Pepper. Journal  of Pharmceutical Sciences and Research. 2013:(10):203-206

• Srinivasan K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Critical Review of Food Science and Nutrition. 2007:47(8):735-48.

• Tasleem F , Azhar I , Ali SN , Perveen S , Mahmood ZA .Analgesic and anti-inflammatory activities of Piper nigrum L. Asian Pacific Journal of Tropical Medicine. 2014: 7S1:S461-8. 

• Zoheir A Damanhouri and Aftab Ahmad. A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices. Medicinal and Aromatic Plants. 2014:3:3.

Penafian: Maklumat pada halaman ini bertujuan pendidikan kesihatan awam dan bukan untuk indikasi ubatan sesuatu produk.

Disclaimer: Information at this page is intended for public health education and not for product claim or indication of a product.

2018 MARKS THE HISTORY OF COMPLETE GXP REQUIREMENT IN MALAYSIA

GXP is a generic acronym used by those in the field of quality assurance of medicinal product development. The words "G" and "P" represents Good and Practice, respectively. While X is a variable whereby "L" for laboratory, "C" for clinical and "M" for manufacturing. Thus, the GXP includes Good Laboratory Practice (GLP), Good Clinical Practice (GCP) and Good Manufacturing Practice (GMP). In the field of agrochemical product development, the variable includes "A" for "agricultural" and "E" for efficacy, i.e representing Good Agricultural Practice (GAP) and Good Efficacy Practice (GEP).

The GXP is documented internationally (e.g. OECD, ICH and ISO) and enforced under national legislation (e.g. FDA). The requirements of GMP and GCP compliance have been enforced by government of Malaysia for decades under the national Drug Control Authority (DCA) that is administered by National Pharmaceutical Regulatory Authority (NPRA), previously known as National Pharmaceutical Control Bureau (NPCB). The 1st January 2018 marks a history whereby NPRA executes the decision by DCA for preclinical safety data of medicinal product that being submitted to adhere the GLP requirement. The decision is consistent with the role of NPRA as the National GLP Compliance Monitoring Authority for medicinal products category.

As the outcome, today requirement for all three of quality assurance systems namely GLP, GCP and GMP in medicinal product development has been implemented. Hence, consumer in Malaysia can look forward to medicinal solution of acceptable safety, efficacy and quality including those developed locally.  Below is the letter of the GLP implementation notice.